-#define serial_out(x,y) outb(x,(ulong)y)
-#define serial_in(y) inb((ulong)y)
+#define serial_out(x, y) outb(x, (ulong)y)
+#define serial_in(y) inb((ulong)y)
+#elif defined(CONFIG_SYS_NS16550_MEM32) && (CONFIG_SYS_NS16550_REG_SIZE > 0)
+#define serial_out(x, y) out_be32(y, x)
+#define serial_in(y) in_be32(y)
+#elif defined(CONFIG_SYS_NS16550_MEM32) && (CONFIG_SYS_NS16550_REG_SIZE < 0)
+#define serial_out(x, y) out_le32(y, x)
+#define serial_in(y) in_le32(y)